Paul’s statement in 2 Timothy 3:16 situates itself at the heart of a letter urging Timothy to remain steadfast amid cultural and theological challenges. ‘All Scripture is given by inspiration of God’ (πᾶσα γραφὴ θεόπνευστος, pasa graphē theopneustos) reveals a distinct claim: Scripture is not merely human wisdom but is ‘breathed out’ by God Himself, denoting origination, authority, and life-giving power. This undergirds the classic doctrine of plenary inspiration—that all canonical writings, Old and (by implication, anticipating canonization) New Testament, derive authority from their divine source (cf. 2 Peter 1:20–21 [https://www.biblegateway.com/passage/?search=2+Peter+1%3A20-21&version=KJV], which describes prophecy as men ‘moved by the Holy Ghost’). Paul details four profitable uses: ‘doctrine’ (teaching the fundamental truths of faith), ‘reproof’ (conviction of error), ‘correction’ (restoration to uprightness), and ‘instruction in righteousness’ (training for godly living). Early Christian theology (e.g., Augustine, Calvin) emphasized that Scripture is the clearest and most sufficient guide for faith and life. The phrase reinforces Sola Scriptura—the Reformation principle that Scripture alone is the ultimate authority for the Church.